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Kratom Half-Life and Duration


Enso
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kratom durationThe question of kratom’s half life is a bit more complex than one might think.

The reason for this is the large amounts of enzymatic and brain interplay between several alkaloids, which all have quite varied half-lives.

Because of the differences among alkaloid half lives, the duration of kratom can very quite dramatically from strain strain to strain and from plant to plant.

For this reason, I will analyze both the half-lives of the prominent alkaloids as well as the kratom duration differences between strains.

This will hopefully give you a better idea of what to expect from each strain.

Contents hide
1. Alkaloid Half-Lives
1.1. What is the Half-life of Mitragynine?
1.2. What is the Half-life of 7-hydroxymitragynine (7-OHM)?
2. Duration by Strain
2.1. Red Vein
2.2. Green Vein
2.3. White Vein

Alkaloid Half-Lives

Although there are 24 identified alkaloids in kratom, as well as many still to be identified.

And only two of these alkaloids do we have a decent understanding of their half lives.

Luckily, these two alkaloids to a large portion of the heavy lifting when it comes to the effects of kratom. These two alkaloids are 7-hydroxymitragynine and mitragynine.

However, because of the slower digestion of plant material, note that kratom half-life alkaloids do not completely describe the duration of its effects.

kratom half life

What is the Half-life of Mitragynine?

The standard half life of mitragynine is 23.24 ± 16.07 hrs [1]. This means that after 23.24 hours, roughly half of the Mitragynine absorbed is still in the body (depending upon the individual’s enzymes and metabolism).

Mitragynine is the most prominent alkaloid found in kratom, and is thought to be responsible for a large portion of kratom’s stimulating effects, as well as some painkilling effects.

What is the Half-life of 7-hydroxymitragynine (7-OHM)?

Despite similar structure to mitragynine, 7-hydroxymitragynine has a typical half life of 2.5 ± .7 hrs [2]. Research on 7-OHM and it’s half-life is still in early stages and is subject to vary as we collect more data.

This alkaloid is by far the most potent painkilling alkaloid found in kratom, despite being only available in minute quantities within the leaf.

The shorter half-life of this alkaloid describes why some of those who suffer from pain prefer smaller doses more frequently throughout the day, to maintain a constant level of 7-hyroxymitragynine.



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Duration by Strain

As you may have noticed, different strains can provide radically different durations of effect. The reasons for this vary, but the primary reasons are:

  • Alkaloid profile
  • Leaf grind density
  • Leaf cell wall density

All three of these contribute to kratom duration, however, for this comparison between vein types and duration, it is assumed that the grind density is the same.

Red Vein

Red vein kratom is by far the most commonly purchased variety because of its pronounced painkilling and mood boosting effects.

As far as kratom duration, red vein strains last fairly long — typically around 4.5 to 6 hours with an average grind. Because of the long duration and high 7-hydroxymitragynine content, it is the most commonly used by those looking for substantial pain relief.

Green Vein

Green vein strains are quite interesting, and can be the longest lasting variety of kratom.

There are a few suspected reasons for this: cell wall density (which many green malaysian strains are a prime example of), and high mitragynine content.

However, they may be more be other factors that contribute to its long duration. While not every green vein is extremely long lasting, some can last an impressive 8 hours.

White Vein

White vein strains, while quite energizing, are one of the shortest lasting strains — typically only around a four hour duration. It is important to note, however, that some rare white vein strains can last quite a bit longer.

Like the green vein, we are not entirely sure why this kratom duration is as different as it is.

Kratom half-life and duration are very tricky concepts, especially due to the lack of research available on these topics. Hopefully within the next few years, we will have enough compiled research to fully understand this unique plant.

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[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425236/

[2] https://www.hindawi.com/journals/bmri/2015/968786/abs/


2 Comments


Seth T.

(Reply)

September 17, 2018, 7:46 pm

where are the sources for this data? it greatly varies from what I’m familiar with (half-life closer to 23 hours), I’d be super interested to review the study(s) this is based on.

    Enso

    (Reply)

    January 6, 2020, 6:05 pm

    Sure! A lot of early kratom studies didn’t appreciate the differences between Mitragynine and 7-OHM. You’re right, but instead it’s Mitragynine’s half-life that’s instead roughly 23 hours.

    There are quite a few newer studies, one of which can be found here:
    https://onlinelibrary.wiley.com/doi/full/10.1002/bmc.2986?casa_token=JkPVFKWVeA8AAAAA%3ACAXv1b_dgd-257WjL1dlBqeouABgmBsTjDUK7ZE5CZMV_YmSJ95T4WSEBWLC_mgDMq0jKrlWGPZjPNg

    This more recent study paints 7-OHM’s half-life as closer to 3 hours. Most recent research I’ve seen puts it at somewhere between 2 and 3 hours, but at this time research is still sparse and lacking.

    Thanks for the motivation to do some legwork! As we get better information, I’ll continue to try to keep this article close to scientific consensus.



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